Manage your multiple personalities with FindMeOn and Profilactic

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. A Nature Research Journal. Herein, we describe a new computational method, called RePlow, that we developed to detect low-VAF somatic mutations based on simple, library-level replicates for next-generation sequencing on any platform. The method is validated in independent cancer panel and brain tissue sequencing data. Our study suggests a new paradigm with which to exploit an overwhelming abundance of sequencing data for accurate variant detection. Next-generation sequencing NGS has afforded researchers the means with which to investigate somatic variants with tremendous accuracy. For many years, the usefulness of NGS was highlighted in cancer research, wherein mutations are clonally expanded and shared by the majority of cancer cells, thereby providing a sufficient variant allele frequency VAF that can be detected in a sample.

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There’s an interesting but rough new service, FindMeOn , that’s tackling a problem that a lot of Web users have: Too many personal profiles. This service is designed to let you create one personal profile on its site, and then export the data to other sites, like Facebook, MySpace, Match. FindMeOn will let you export just pieces of your profile to specific sites. You might want to leave out your age or religious affiliation on MySpace, for example, but include such info on a dating site.

What if you want to say different things on different sites? I don’t know if FindMeOn will address that. The site is in the “preview” stage right now, and from a usability perspective it’s pretty much impenetrable. So I can’t recommend that you put effort into it yet. But it’s a neat idea and I hope the team does the necessary work on it to make it easy to use.

There’s another site in development, and not yet open to users: Profilactic. Normally I don’t comment on product names, but I will here: Yuck. This service will aggregate the content from your various social sites MySpace, Flickr, Digg, etc. It sounds to me like it’ll be creating, essentially, a meta-profile page–one that’s made up of all your online personalities. If you want to keep your personalities different on different sites, that’s not something you’re going to want to share.

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FindMeOn will let you export just pieces of your profile to specific sites. affiliation on MySpace, for example, but include such info on a dating site. saying in the comments fields on all your profiles, though many profile sites.

Meanwhile, heat 1 tablespoon of the oil in a large skillet over medium-high heat. In 2 batches, cook the steak until browned, about 1 minute per side. Transfer to a plate. Return the skillet to medium heat and add the remaining oil. Add the mushrooms and shallots; cook, stirring occasionally, until tender, 5 to 6 minutes.

Add the wine and simmer until the liquid has reduced by half, 2 to 3 minutes.

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Updated visitor guidelines are in place for patients in the hospital and Emergency Department and all staff and visitors are now required to wear protective masks. Learn more. Your health and safety are our top priority. See Our Safety Plans. Telehealth is a safe, secure way to receive care. We are offering telehealth appointments for most outpatient services.

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Tax scams can still target you after you’ve filed your taxes. What to know and do

Tax Day in July is a phrase none of us ever expected to hear, and yet, here we are. But don’t get too complacent. Fraudsters will continue trying to scam or trick tax filers out of their personal information and refunds for weeks to come. Tax fraud and scams are an issue the IRS takes seriously and does its best to warn us about. Here’s a shortlist of some of the most common scams making the rounds — and what to do to keep both your identity and tax return safe and secure, including reporting the trick to the IRS.

How it works: One of the most brazen schemes used every year is scammers calling and claiming to represent the IRS to taxpayers and demand an immediate tax payment.

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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. A Nature Research Journal. Meanwhile, GPC2 tumors show elevated oxidative phosphorylation-related proteins, differentiated oligodendrocyte and astrocyte markers, and a favorable prognostic biomarker, phosphoglycerate dehydrogenase PHGDH.

Our analyses will guide GBM prognosis and precision treatment strategies. Glioblastoma multiforme GBM is a lethal form of adult brain cancer with a median overall survival time of 12—15 months 1.

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A novel coronavirus is a new coronavirus that has not been previously identified. There are many types of human coronaviruses including some that commonly cause mild upper-respiratory tract illnesses. COVID is a new disease, caused by a novel or new coronavirus that has not previously been seen in humans. The virus that causes COVID is thought to spread mainly from person to person, mainly through respiratory droplets produced when an infected person coughs, sneezes, or talks.

These droplets can land in the mouths or noses of people who are nearby or possibly be inhaled into the lungs. Spread is more likely when people are in close contact with one another within about 6 feet. Community spread means people have been infected with the virus in an area, including some who are not sure how or where they became infected.

It may be possible that people can get COVID by touching a surface or object, such as a food package or dining ware that has the virus on it and then touching their own mouth, nose, or possibly their eyes. However, this is not thought to be the main way the virus spreads. Conventional water treatment methods that use filtration and disinfection, such as those in most municipal drinking water systems, should remove or kill the virus that causes COVID Some other viruses, like those that cause the common cold and flu, spread more during cold weather months but that does not mean it is impossible to become sick with these viruses during other months.

There is much more to learn about the transmissibility, severity, and other features associated with COVID and investigations are ongoing. Each health department determines community spread differently based on local conditions.

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